http://binarymetabot.com/blood-pressure-protocol-ebook-review/Blood Pressure Protocol


Over the past 20 years, research scientists have attempted to non-invasively measure mice and rat blood pressure (BP) with varying degrees of success.
The ability to accurately and non-invasively measure the systolic and diastolic blood pressure, in addition to the heart pulse rate and other blood flow parameters in rodents, is of great clinical value to the researcher.

Invasive Blood Pressure, Rat and Mouse Measurement

Direct blood pressure, an invasive surgical procedure, is the gold standard to compare the accuracy of non-invasive blood pressure (NIBP) technologies. Direct blood pressure should be obtained on the rodent’s carotid artery when comparing to NIBP. “Validation in Awake Rats of a Tail Cuff Method for Measuring Systolic Pressure”, Bunag, R.D., Journal of Applied Physiology, Vol 34, Pgs 279-282, 1973.

Radiotelemetry, a highly invasive surgical procedure, is a very reliable blood pressure technology and is also utilized to compare the accuracy of NIBP technologies. Telemetry involves the implantation of radio transmitters in the rodent’s body. This technique is well validated and has excellent correlation with direct blood pressure.

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